Days after establishing a new club record with their 12th straight win, Napoli aim to extend that streak at home to Sassuolo on Saturday afternoon.
The Serie A leaders continue their Scudetto quest at Stadio Maradona, where they crushed Rangers 3-0 in midweek, and now face a mid-table side desperately seeking some consistency.
Following their midweek exit from Europe, an ailing Juventus side return to Serie A duty on Saturday, as they visit lowly Lecce at Stadio Via del Mare.
Beaten for the fourth time in five Champions League games, Juve are now set to drop into the Europa League, but first must make up ground on the seven clubs above them in Italy, as they seek a third league win on the spin.
After securing their spot in the Champions League’s last-16, Inter Milan return to Serie A duty on Saturday night, as they aim to make up lost ground by beating struggling Sampdoria.
While Inter cruised to a fifth win from six matches in midweek, Samp scrapped out their first league victory of the season at Cremonese, and now former Nerazzurri star Dejan Stankovic returns to San Siro seeking a major upset.